lecture 26 - Lecture 26. Friday (4-1-11) Exam 2, 2011 Exam...

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Lecture 26. Friday (4-1-11)
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Exam 2, 2011 Exam 2, 2011
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Which of these do you think had a signal sequence?
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Lysosomal enzyme targeting by Mannose-6-P 1. An enzyme destined for the lysosome is phosphorylated on a mannose sugar in the cis golgi. Where was is made? 2. Mannose-6-P receptors in trans golgi bind this protein and packages it into vesicles 3. Clathrin binds to the outside of these vesicles, targeting them to become lysosomes 4. The lysosomal enzyme is released from the receptor as the lysosome matures 5. Clathrin is released and the receptors are recycled to the golgi 6. Some mannose-6-P receptors that ended up on the plasma membrane are retrieved and recycled. How did they get there? Which of the enzymes in Table 8-1 do you think had mannose-6-P on them?
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1. Particles are brought in by endocytosis 2. The vesicle formed inside the cell is called a phagosome 3. Lysosomes fuse with phagosomes and transfer their hydrolytic enzymes inside, creating a phagolysosome 4. The particle gets digested and nutrients pass into the cytoplasm 5. The leftover, non-digestible material (garbage) is dumped out from residual bodies by exocytosis. This is where some mannose-6-P receptors can make it to the plasma membrane 1. 2.
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This note was uploaded on 07/26/2011 for the course BIO 201 taught by Professor Janicke during the Spring '08 term at SUNY Buffalo.

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lecture 26 - Lecture 26. Friday (4-1-11) Exam 2, 2011 Exam...

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