Lecture 31 - Lecture 31 Mitosis Cell cycle M-phase...

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Lecture 31
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Mitosis Cell cycle
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Phases of Mitosis Anaphase A Anaphase B Kinetochores M-phase FOCUS ON THIS SLIDE!!
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Chromatin cohesion in S-phase and compaction (condensing) in prophase of mitosis
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Cohesin helps to keep the two pieces of chromatin together after S- phase, through G2 and into the beginning of prophase Phosphorylation of cohesin in early prophase causes a loss of cohesin between homologous chromatids except near the centromere Would you expect to see any cohesin connections in anaphase?
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Condensin helps to compact and supercoil DNA in prophase What phases of the cell cycle would have the most condensin associated with chromatin? Prophase, prometaphase, metaphase, anaphase
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Which phases of the cell cycle would have the most cohesin associations with chromatin? Very early prophase “sister chromatid cohesion”
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Phases of Mitosis Condensin goes to work in prophase Cohesin holds together the sister chromatids at their centromeres Cohesin lets go in anaphase Condensin starts to disappear in telophase and the chromatin becomes disperse
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A scaffold of cohesin, condensin and other proteins helps to hold the DNA in the mitotic chromosomes The book only says that histones and most of the other proteins were removed for this figure. How?
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Lecture 31 - Lecture 31 Mitosis Cell cycle M-phase...

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