Neurotransmitters

Neurotransmitters - AMINO ACIDS Glutimate Most common...

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AMINO ACIDS Glutimate Most common excitatory transmitter Both ionotrophic and metabotrophic receptors Ion channels: AMPA - bind glutimate, opens channel Kainate NMDA - sensitive to voltage as well as glutimate ligand Has to have depolarization of certain threshold When people have brain injury (stroke/trauma), so many cells produce glutimate that it gets released --> Excitotoxicity : Glutimate release produces prolonged depolarization of postsynaptic cells. Overexcitation ultimately kills postsynaptic cells. GABA Ionotrophic and metabotrophic receptors: GABA A , GABA C = Ionotrophic, sensitive to Cl - => inhibitory! GABAB = Metabotrophic Valium acts on GABAA receptors, increasing GABA activity and tranquilizing patient Anxiolytics = anxiety, "tranquilizers" (depressants) Benzodiazepines, ex) Valium --> drug binds to a modulatory site on the receptor Orphan Receptor - receptor for which an endogenous ligand has not been identified PEPTIDES More diverse (number, functions => postsynaptic potential to hormonal effects) Typically receptors are metabotrophic
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Neurotransmitters - AMINO ACIDS Glutimate Most common...

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