This preview shows pages 1–3. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: RB Phosphorylation conformational shift Can no longer bind E2F o The protein stimulates S cyclin and G1/S cyclin o Feedback loops further enhances synthesis o G1/S cyclin-Cdk phosphorylates RB o More active S-Cdk, which drives DNA synthesis Tumor suppressor, when normal it suppresses growth and moving too soon through S 14/07/2011 11:14:00 14/07/2011 11:14:00...
View Full Document