review - RB Phosphorylation conformational shift Can no...

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14/07/2011 11:14:00 1 st generation dispersive – 50, 50 – one is a mixture of N15 and N14 and one is N14 and N14 2 nd and 3 rd generation – reduces N15, spin down DNA you get one strand because each strand is the same (each strand has a little bit of N15 and a lot more of N14) one band will slowly migrate up At each origin of replication, you synthesize in both directions DNA polymerase III DNA polymerase I doesn’t have Klenow
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Unformatted text preview: RB Phosphorylation conformational shift Can no longer bind E2F o The protein stimulates S cyclin and G1/S cyclin o Feedback loops further enhances synthesis o G1/S cyclin-Cdk phosphorylates RB o More active S-Cdk, which drives DNA synthesis Tumor suppressor, when normal it suppresses growth and moving too soon through S 14/07/2011 11:14:00 14/07/2011 11:14:00...
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This note was uploaded on 07/27/2011 for the course BIO 2960 taught by Professor Staff during the Spring '08 term at Washington University in St. Louis.

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review - RB Phosphorylation conformational shift Can no...

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