ebn - FAR EASTERN UNIVERSITY Institute of Nursing EVIDENCE...

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FAR EASTERN UNIVERSITY Institute of Nursing EVIDENCE BASED NURSING (Musculoskeletal Disorders) Submitted by: Igat, Rydal BSN034 Submitted to: C.I. Charmaine Damasco
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I. Clinical Question What is the effect of Chondroitin on pain in patients with osteoarthritis? II. Citation Meta-analysis: Chondroitin for Osteoarthritis of the Knee or Hip III. Study Characteristics 1. The population studied is 3846 patients with osteoarthritis on knee or hip for 20 trials. 2. The interventions compared were the effect sizes were calculated from the differences in means of pain-related outcomes between treatment and control groups at the end of the trial, divided by the pooled SD. 3. The prespecified primary end point was pain at the end of the trial or at a maximum of 3 months after termination of chondroitin therapy (whichever came first). When an article provided data on more than 1 pain scale, we referred to a previously described hierarchy of pain related outcomes (18) and extracted the outcome that was highest on this list. 4. The study focuses on a significant problem to test or found out some solutions on the interventions for the occurrence of osteoarthritis. IV. Methodology/Design 1. Studies were included if they were randomized or quasi-randomized, controlled trials that compared chondroitin with placebo or with no treatment in patients with osteoarthritis of the knee or hip. 2. The design used on the study is randomized design or quasi-randomized design. 3. Small trials, trials with unclear concealment of allocation, and trials that were not analyzed according to the intention to treat principle showed larger effects in favor of chondroitin than did the remaining trials. When the authors restricted the analysis to the 3
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This note was uploaded on 07/27/2011 for the course NURSING N219.6 taught by Professor Dr.tuazon during the Spring '09 term at University of the Philippines Los Baños.

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ebn - FAR EASTERN UNIVERSITY Institute of Nursing EVIDENCE...

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