10-1_1_PM_Herpesviruses

10-1_1_PM_Herpesviruses - Herpesviruses Herpes simplex I...

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Herpesviruses Herpes simplex I & II (cold sores, genital herpes) Varicella zoster (chicken pox, shingles) Cytomegalovirus (microcephaly, infectious mono) Epstein-Barr virus (mononucleosis, Burkitt’s lymphoma) Human herpesvirus 6 & 7 (Roseola) Human herpesvirus 8 (Kaposi’s sarcoma)
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Cold Sores
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Zoster
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Roseola
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Virus Subfamily Disease Site of Latency Herpes Simplex Virus I α Orofacial lesions Sensory Nerve Ganglia Herpes Simplex Virus II α Genital lesions Sensory Nerve Ganglia Varicella Zoster Virus α Chicken Pox Sensory Nerve Ganglia Recurs as Shingles Cytomegalovirus β Microcephaly/Mono Lymphocytes Human Herpesvirus 6 β Roseola Infantum CD4 T cells Human Herpesvirus 7 β Roseola Infantum CD4T cells Epstein-Barr Virus γ Infectious Mono B lymphocytes, salivary Human Herpesvirus 8 γ Kaposi’s Sarcoma Kaposi’s Sarcoma Tissue Human Herpesviruses
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Herpes Simplex Virus Prototype of group
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Virion stabiliy Enveloped virus Sensitive to dessication Easily inactivated by detergents and lipid solvents
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Virion structure Enveloped, spherical virion Icsoahedral capsid 120 - 200 nm >12 virally encoded glycoproteins Tegument proteins
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Genome structure Linear double-stranded DNA 120 - 230 kb Genetic complexity -- isomers
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Genome structure Linear double-stranded DNA 120 - 230 kb Genetic complexity # of genes
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Replication Penetration by fusion with plasma membrane Nuclear site of replication 80 or so viral proteins are expressed in regulated fashion: IE - immediate early E - Early L - Late Capsids assemble in nucleus and bud through nuclear membrame
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Life-long Latency
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Three manifestations of HSV latency Key Feature:
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10-1_1_PM_Herpesviruses - Herpesviruses Herpes simplex I...

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