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10intro3-bw - Bacterial Pathogenesis Infectious disease =...

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10/10/2010 1 Bacterial Pathogenesis Infectious disease = cycle of biological interactions Most interventions in preventing infectious disease do not directly involve the physician. By understanding the complete process of bacterial pathogenesis, you will be better equipped to aid in intervention and prevention at the numerous steps other than by administering antibiotics or vaccines. Bacterial Pathogenesis There is order to the universe! Your favorite movie… Clichés Learn the basic story lines and key points Not the 100 x 100 grid Definitions and concepts Disease damage caused by presence of microorganisms or their products (can be inapparent or without observable symptoms at a point in time). Colonization presence of microorganisms without disease at that point. This term applies to surfaces only , i.e., the blood cannot be colonized and host cells with intracellular infection are not colonized. Infection an important but sometimes ambiguous term! When referring to a patient , "infection" always means disease (opposite of colonization). E.g., if a person has Staphylococcus aureus in their nose, but has no symptoms, they are colonized. As soon as symptoms appear (e.g., an inflamed hair follicle with pus and pain), they have an infection. When referring to a specific site in the body, infection can mean the simple presence of microbes without referring to disease or not. In the example immediately above, we could say that the staphylococci had "infected" the nares before they actually caused disease. Because of this semantic issue, we will make sure that the term is clarified on exams. If you are ever in doubt of what it means during discussions of patients or diseases, you should ask. We will make every attempt to define the term with modifiers such as "asymptomatic", "inapparent", etc., when appropriate. Carrier state - colonization with a pathogen Pathogen - any organism that has the potential to cause disease Overt (strict, primary) vs. Opportunistic pathogens overt pathogens have a high probability of causing disease in an otherwise healthy host opportunistic pathogens have a low probability and usually require a debilitated or compromised host
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10/10/2010 2 Normal flora Definition - frequently found on or within the body of healthy persons They can cause disease under the right conditions ( endogenous infection/disease )
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