{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Chapter 5 - Chapter 5 Methods and Strategies of Research...

Info icon This preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 5 Methods and Strategies of Research
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Research methods Scientific investigation entails a process of asking questions of nature The best conclusions about the physiology of behavior are made not by any single experiment, but by a program of research that enables us to compare the results of studies that approach the problem with different methods
Image of page 2
Experimental ablation The removal or destruction of a portion of the brain of a lab animal; presumably, the functions that can no longer be performed are the ones the region previously controlled Oldest method in neuroscience
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Evaluation the behavioral effects of brain damage Lesion study (i.e. experimental ablation) Must be very careful about interpreting effects of lesion: Just because certain functions appear to be missing, doesn’t mean they were necessary for some type of behavior Circuits within the brain perform functions, not behaviors No one brain region or neural circuit is solely responsible for a behavior Also, all regions of brain are interconnected; i.e. if you disrupt one neural circuit to affect a certain behavior, you may end up affecting other behaviors too
Image of page 4
Producing brain lesions Immediately underneath the skull: Anesthetize animal, cut scalp, remove part of skull, cut through dura mater, and use suction device (e.g. pipette) to remove brain material For deeper brain tissue Use electrode to burn away tissue – very general, destroys all surround tissue, cells Excitotoxic lesions – e.g. kainic acid – kills neurons by stimulating them to death; more focused technique 6-hydroxydopamine – chemical selectively taken up by axons and terminal buttons of NE or DA neurons and acts as poison, killing them; selective method However, passing an electrode through or injecting chemical into brain tissue can destroy other tissue along the way Control group – sham lesions
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern