Chapter 5 - Chapter 5 Methods and Strategies of Research...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 5 Methods and Strategies of Research
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Research methods Scientific investigation entails a process of asking questions of nature The best conclusions about the physiology of behavior are made not by any single experiment, but by a program of research that enables us to compare the results of studies that approach the problem with different methods
Background image of page 2
Experimental ablation The removal or destruction of a portion of the brain of a lab animal; presumably, the functions that can no longer be performed are the ones the region previously controlled Oldest method in neuroscience
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Evaluation the behavioral effects of brain damage Lesion study (i.e. experimental ablation) Must be very careful about interpreting effects of lesion: Just because certain functions appear to be missing, doesn’t mean they were necessary for some type of behavior Circuits within the brain perform functions, not behaviors No one brain region or neural circuit is solely responsible for a behavior Also, all regions of brain are interconnected; i.e. if you disrupt one neural circuit to affect a certain behavior, you may end up affecting other behaviors too
Background image of page 4
Producing brain lesions Immediately underneath the skull: Anesthetize animal, cut scalp, remove part of skull, cut through dura mater, and use suction device (e.g. pipette) to remove brain material For deeper brain tissue Use electrode to burn away tissue – very general, destroys all surround tissue, cells Excitotoxic lesions – e.g. kainic acid – kills neurons by stimulating them to death; more focused technique 6-hydroxydopamine – chemical selectively taken up by axons and terminal buttons of NE or DA neurons and acts as poison, killing them; selective method However, passing an electrode through or injecting chemical into brain tissue can destroy other tissue along the way Control group – sham lesions
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 16

Chapter 5 - Chapter 5 Methods and Strategies of Research...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online