Outline_Chapter_13 - Chapter 13 Microbe-Human Interactions:...

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Chapter 13 Microbe-Human Interactions: Infection and Disease Chapter Outline 13.1. The Human Host A. Contact, infection, disease—A continuum 1. Microbes invade the tissues leading to infection 2. Pathologic state that results in damage or disruption of organs or tissues is known as a disease 3. Infectious disease: disruption of a tissue or organ caused by microbes and their products B. Resident biota: The human as a habitat 1. Normal resident biota or indigenous biota 2. Acquiring resident biota a. Human body has wide variety of environmental niches that vary in: i. Temperature ii. pH iii. Nutrients iv. Oxygen tension b. Most areas of the body in contact with the outside environment harbor biota c. Internal organs and tissue, including fluids, are generally microbe-free d. Bacterial biota can benefit the human host by preventing overgrowth of harmful microbes: i. Fermentation of glycogen by lactobacilli keeps pH in vagina very acidic ii. Prevents the overgrowth of the yeast Candida albicans e. Immunosuppression such as AIDS i. Normal biota can lead to infection in these patients ii. Streptococcus pneumoniae and pneumococcal pneumonia f. Endogenous infections can occur when normal biota is introduced into a previously sterile site 3. Initial colonization of the newborn a. First exposure is the breaking of the fetal membranes, when vaginal microbes can enter the womb b. Comprehensive exposure during passage through birth canal c. Large intestine microbiota: i. Bottle-fed infants have coliforms, lactobacilli, enteric streptococci, and staphylococci ii. Breast-fed infants have Bifidobacterium C. Indigenous biota of specific regions: Table 13.3 1. Biota of human skin 2. Biota of the gastrointestinal tract a. Biota of the mouth b. Biota of the large intestine i. Bacteroides, Bifidobacterium, Fusobacterium, Clostridium ii. Small amounts of
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This note was uploaded on 08/02/2011 for the course MICRO 233 taught by Professor Diaz during the Fall '10 term at City Colleges of Chicago.

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Outline_Chapter_13 - Chapter 13 Microbe-Human Interactions:...

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