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Outline_Chapter_14 - Chapter 14 Host Defenses I Overview...

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Chapter 14 Host Defenses I: Overview and Nonspecific Host Defenses Chapter Outline 14.1. Defense Mechanisms of the Host in Perspective A. Host defenses are a network of nonspecific and specific immunities known as: 1. First line of defense 2. Second line of defense 3. Third line of defense B. Barriers at the portal of entry: A first line of defense 1. Physical or anatomical barriers at the body's surface a. Skin b. Mucous membranes c. Blinking reflexes and tears d. Respiratory tract: i. Ciliary escalator ii. Nasal hair iii. Sneezing, coughing e. Urination 2. Nonspecific chemical defenses a. Sebaceous antimicrobial secretions b. Lysozyme in tears and saliva c. Electrolytes, lactic acid, pH defenses 3. Genetic defenses in susceptibility 14.2. The Second and Third Lines of Defense: An Overview A. Surveillance of the body B. Recognition of foreign material C. Destruction of entities deemed foreign 14.3. Systems Involved in Immune Defenses A. The communicating body compartments 1. Immune functions of the reticuloendothelial system a. Mononuclear phagocyte system 2. Origin, composition, and functions of the blood a. Whole blood, cells and plasma b. Serum c. Fundamental characteristics of plasma i. 92% water ii.
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