A3 The Erythgocyte - metabolism

A3 The Erythgocyte - metabolism - Erythrocyte Metabolism...

Info iconThis preview shows pages 1–17. Sign up to view the full content.

View Full Document Right Arrow Icon
Erythrocyte Metabolism
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
RBC and electrolyte/ fluid balance RBC membrane is a semi-permeable membrane It allows certain substances to pass through the membrane, inhibits the passage of other substances, while actively moving some substances through the membrane. RBCs have a high concentration of potassium (K), Sodium is in a high concentration in the plasma
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
As a result of diffusion sodium and water have a tendency to enter the cell This would result in the cells swelling and lysing (hemolysis) The cell uses energy to pump out the sodium and maintain water balance
Background image of page 4
Increase intracellular water
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Energy ATP is a substance that provides energy for the body and rbc It is derived by glycolysis (the biochemical process of using glucose for energy. Every mole of glucose provides a net of 2 moles of ATP
Background image of page 6
One mole of glucose produces two ATPs
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
Emden-Meyerhof Pathway (Glycolytic Pathway) Metabolic pathway of glucose
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Embden-Meyerhof Pathway Glucose taken into the RBC is metabolized through a series of reactions catalyzed by enzymes This results in the production of two moles of ATP The ATP provides the energy needed for the RBC to maintain itself Glucose is the primary source of energy for the RBC
Background image of page 10
A genetic defect that results in a decrease in an enzyme in the metabolic pathway, results in decrease production of ATP Therefore decrease in energy Decreased survival of the RBC Hemolytic anemia Pyruvate kinase enzyme deficiency does occur, resulting in decreased rbc survival
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
Hexose monophosphate shunt Reduction of hemoglobin
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Hexose monophosphate shunt When needed, the glycolytic pathyway can take another route, known as the hexose monohosphate shunt This pathway results in the reduction of the sulfhydral bonds in the globin of hemoglobin
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Precipitation of hemoglobin Chemicals (medications, etc) can oxidize the sulfhydral bonds of the globin portion of hemoglobin This oxidation can result in the precipitation of hemoglobin The chemical reactions cause the oxidized hemoglobin to be reduced, thus preserving the rbc
Background image of page 16
Image of page 17
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 60

A3 The Erythgocyte - metabolism - Erythrocyte Metabolism...

This preview shows document pages 1 - 17. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online