Chapter 18,19 - 1 Chapters 18 + 19 Kidneys 1. Regulate...

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Unformatted text preview: 1 Chapters 18 + 19 Kidneys 1. Regulate plasma volume (B.P.). 2. Regulate concentration of electrolytes (e.g. Na + , K + , HC0 3- ). 3. Regulate pH ([H + ]). 4. Regulate concentration of waste products in the blood. 5. Secrete erythropoietin. Chapter 18 Renal Function Cortex : Filtration occurs here. Many capillaries. Medulla : Filtrate flows into minor then major calyces, renal pelvis, ureter Nephron = functional unit of kidney Nephron Tubules Bowmans Capsule Proximal convoluted tubule (PCT) Loop of Henle (LH) Distal convoluted tubule (DCT) Collecting duct (CD) 2 Renal Blood Vessels Afferent arteriole : Delivers blood into the glomerulus. Glomerulus : Capillary network produces filtrate that enters the urinary tubules. Efferent arteriole : Delivers blood from glomeruli to peritubular capillaries and vasa recta Peritubular Capillaries + Vasa Recta Capillaries surrounding tubules Renal Exchange Filtration Reabsorption most filtered substances Secretion- Allows kidneys to rapidly eliminate certain potential toxins Glomerular Filtration Membrane Large capillary pores called fenestrae (100-400 times more permeable than other capillaries). Pores are still small enough to prevent RBCs and proteins from passing through. Ultrafiltrate fluid that enters the Bowman's Capsule (primarily by blood pressure) 3 Glomerular Filtration GFR (glomerular filtration rate): Volume of filtrate produced by both kidneys/min Averages 125 ml/min or 180 L/day. Measured using [Inulin] Vasoconstriction or dilation of afferent arterioles affects the rate of blood flow to the glomerulus, and therefore the GFR. Intrinsic control (Autoregulation). Sympathetic Nervous System. Hormonal: Renin-angiotension. Intrinsic Control (Autoregulation) Ability of kidney to maintain a constant GFR under systemic changes in mean arterial pressure. Achieved through effects of locally produced chemicals and stretch receptors....
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Chapter 18,19 - 1 Chapters 18 + 19 Kidneys 1. Regulate...

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