Drugs&Brain_2011

Drugs&Brain_2011 - with chronic drug exposure that...

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! Neurotransmitter release ! Ion release ! Neurotransmitter reuptake ! Receptor numbers/binding characteristics ! Intracellular signaling pathways
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Pidoplichko et al., 2004
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Wolf, 2003
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Excessive and/or repeated drug exposure can lead to receptor desensitization/internalization
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The changes that occur during repeated drug exposure can produce an opposite effect when the drug is removed.
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Drugs may actually increase the activity of certain types of neurons Wolf, 2003
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New systems are recruited
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Unformatted text preview: with chronic drug exposure that contribute to withdrawal. Learning processes are heavily involved in the process of addiction Koob & Volkow, 2010 BLUE: Basic reward circuitry RED: Negative reinforcement/withdrawal GREEN: Relapse & craving Euphoria Reward " DA Habits Perseveration Decreased reward # DA # 5-HT Malaise Dysphoria Negative emotional states Koob, 2008 Benes, 2010 Craving Executive functioning Conditioned cues (learning) Drugs mess with your brain!!...
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Drugs&Brain_2011 - with chronic drug exposure that...

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