Chem 30CL- Lecture 1c

Chem 30CL- Lecture 1c - Lecture 1c Click to edit Master...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
Click to edit Master subtitle style 8/6/11 Asymmetric synthesis Lecture 1c
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8/6/11 Hanson, J., J.Chem.Educ. 2001 , 78(9) , 1266 (including supplemental material ). Larrow, J.F., Jacobsen, E.N., Org. Synth. 1998 , 75 , 1. Cepanec, I. et al., Synth. Commun . 2001 , 31(19) , 2913. Flessner, T., Doye, S., J.Prakt.Chem. 1999 , 341 , 436. McGarrigle, E.M., Gilheany, D.G., Chem.Rev. 2005 , 105(5) , 1563. Schurig, V., Nowotny, H.P., Angew.Chem. Int. Ed. Engl . 1990 , 29(9) , 939. Assigned reading
Background image of page 2
8/6/11 Chirality plays important key role in many biological systems Many drugs are single enantiomer drugs because often only one enantiomer is active in a desirable fashion while the other enantiomer is harmful Some of these drugs are isomerized in vivo (*) Why asymmetric synthesis? Drug R-form S-form Thalidomide Morning sickness Teratogenic* Ibuprofen Slow acting Fast acting* Prozac Anti- depressant Helps against migraine N O O * NH O O COOH
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8/6/11 History of Asymmetric Synthesis I
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 9

Chem 30CL- Lecture 1c - Lecture 1c Click to edit Master...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online