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Unformatted text preview: movement. Skeletal Muscle Structure Muscle fibers are multinucleated, with the nuclei located just under the plasma membrane. The thick filaments are made of myosin and occupy the center of each sarcomere. Thin filaments are made of actin and anchor to the Z line. The head of the myosin molecule is marked by a large cleft extending from the actin binding site on one side to the ATP-binding site/pocket on the other. A cleft of this nature leads to a possibility of coupling between the two sites through conformational changes. This allows for the movement of the head about the neck region and the sequential binding of actin and ATP. 1 2...
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- Winter '09