Lecture Notes 2.1

Lecture Notes 2.1 - Real bioprocesses vs Harrisons rules...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
Real bioprocesses vs Harrison’s rules TKB 090821
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Harrison’s (and Belter’s) bioprocess “stages” Stage 1 – removal of insolubles Filtration and centrifugation typical No volume reduction Stage 2 – isolation of product Separate product from impurities that are grossly different Often via adsorption or solvent extraction Seek volume reduction Stage 3 – purification Separate product from impurities similar to it Often via chromatography or precipitation Stage 4 – polishing Leaves product in a useful form - stable and transportable Crystallization typical
Background image of page 2
3 Harrison’s bioprocess heuristics Rule 1 – Remove the most plentiful impurities first Rule 2 – Remove the easist-to-remove impurities first Rule 3 – Make the most difficult and expensive separations last Rule 4 – Select unit ops that leverage the greatest differences in properties between product and impurities Rule 5 – Select unit ops that apply different (orthogonal) driving forces (separation mechanism
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 CASE 1 - bioprocesses for citric acid Large volume, > 1 million ton/yr Fermentor broth vol/batch ≈ 50 – 250 m Flavor enhancer and preservative for foods, beverages.
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 08/09/2011 for the course CHEN 4820 at Colorado.

Page1 / 19

Lecture Notes 2.1 - Real bioprocesses vs Harrisons rules...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online