Somatogen Story

Somatogen Story - Why processes matter - the Somatogen...

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Why processes matter - the Somatogen Story THE NEED - the Holy Grail of Emergency Medicine THE IDEA - use recombinant DNA technology to engineer a unique hemoglobin that can be given to paitients as a pure solution.
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Native human hemoglobin A hemoprotein w 4 subunits (2 α , 2 β ) and 4 hemes (where O 2 binds)
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Red blood cells create a special environment: 1 - DPG modulates O 2 binding Somatogen changed the amino acids near the heme groups to compensate for the absence of DPG.
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Heme Groups in Hemoglobin
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Red blood cells create special environment: 2 –combats oxidation, discourages dissociation 1. Somatogen process stripped oxygen from product, and packaged it in gas-impermeable bag. 2. Somatogen added a glycine crosslink to tie together the two β subunits to prevent dissociation. α 2 β 2 αβ + αβ Fe(II) heme Fe(III) heme + e -1 RBC reducing enzymes
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develop a billion dollar product
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Somatogen Story - Why processes matter - the Somatogen...

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