02.10.10 - Feb 10th Malaria Vector of Plasmodium are highly

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Feb 10 th Malaria Vector of Plasmodium are highly temperature-sensitive. 4 species are infectious to humans and 156 species infectious to animals. Death predominantly in children and pregnant women. Repeated exposure confers semi-immunity (infected but don’t get sick), though if individual is isolated from exposure they may lose this immunity. P.falciparum: most common, acute P.vivax: next most common, can remain for 5-10 years P.ovale: derived from P.vivax in response to mutation P.malariae: rarer Local population variances exist, therefore no simple rules to eliminate the vector. Heterozygote haemoglobin (sickle cell): are immune to malaria, thus malaria alters human genetics Historically, more humans have died from malaria than weapons in wars. Once anti- malarial drugs were discovered, they became heavily used by solders and R&D funded by US army. Europeans were resistant in the colonization of Africa due to malaria. Development: 1930’s there was a 30% incidence of malaria along the Mississippi River surrounding New Orleans China pretty well cleared of malaria P.faciparum threaten Africa, P.vivax dominant threat
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02.10.10 - Feb 10th Malaria Vector of Plasmodium are highly

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