LS_2_Lec_10_Muscles

LS_2_Lec_10_Muscles - Life Sciences 2 Chapter 48...

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Life Sciences 2 Chapter 48 Musculoskeletal Systems Dr. Jospeh Esdin Neural Pathway Skin receptors Sensory neuron Interneuron Motor neuron Effector
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Classification of Muscles • Muscles are contractile tissue • 3 types – Skeletal (voluntary) – Smooth (involuntary) – Cardiac (involuntary) Skeletal Muscles • Each muscle in the body is classified as an organ • A muscle is made of many fascicles • Fascicles are made of muscle fibers • Muscles fibers are made of myofibrils • Myofibrils are contractile proteins
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Levels of Organization Fascicle Muscle Muscle fiber Sarcomere • Each myofibril is made of functional units of contraction called sarcomeres • Each sarcomere is bound by a network of interconnecting proteins called Z lines • Thick filaments are composed of a contractile protein (myosin) Levels of Organization in Skeletal Muscles
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Levels of Organization in Skeletal Muscles • Thin filaments contain a contractile protein (actin) and two regulatory proteins (troponin) and (tropomyosin) Sarcomere Thick filament Thin filaments Z line
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Thick filament Myosin Actin Thin filament Filaments Troponin Tropomyosin Thick Filaments Thick filament Myosin molecules Myosin head Myosin tail Actin binding site ATP binding site [ Cross bridge
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Thick Filaments • Each thick filament is made of arranged myosin molecules • Each myosin molecule is made of two heads and two tails • Each myosin head contains an actin binding site and an ATP binding site Thin Filaments • Thin filaments are made of three proteins • Actin, troponin, & tropomyosin
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This note was uploaded on 08/15/2011 for the course LS 2 taught by Professor Pires during the Spring '08 term at UCLA.

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LS_2_Lec_10_Muscles - Life Sciences 2 Chapter 48...

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