Lecture 13 - 020211

Lecture 13 - 020211 - Lecture 13 Pentose Phosphate Pathway...

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1 Lecture 13 Pentose Phosphate Pathway
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2 Pentose Phosphate Pathway Required for generation of NADPH Also produces Ribose-5-phosphate (R5P) for nucleotide biosynthesis
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3 Compartments Pentose phosphate Pathway — cytoplasm
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4 Nicotinamide as carrier of electrons
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5 NAD + vs. NADP + Small chemical difference, big biological difference
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6 NAD + NADP + Capture energy from metabolism Capture energy from metabolism For ATP generation through oxidative phosphorylation For reductive biosynthesis (fatty acids and cholesterol) NAD + /NADH 1000/1(favors metabolite oxidation) NADP + /NADPH 1/100 (favors reductive biosynthesis) Selective dehydrogenases Selective dehydrogenases
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7
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Pentose Phosphate Pathway Where does glucose 6- phosphate come from? 8
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9 First step of glycolysis — Hexokinase First step: Getting a phosphate on carbon #6. PO 3 2- ATP + + ADP + H + Glucose Glucose-6- phosphate (G6P)
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10 Instead of second step of glycolysis, Phosphoglucose Isomerase Use Glucose-6- phosphate dehydrogenase 10
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Pentose Phosphate Pathway: Phase 1 Oxidation: electron acceptor NADP + Glucose 6-posphate dehydrogenase specific for NADP + 11
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Pentose Phosphate Pathway: Phase 1 Oxidation: electron acceptor NADP + Hydrolysis 12
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Lecture 13 - 020211 - Lecture 13 Pentose Phosphate Pathway...

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