Lecture 14 - 020711

Lecture 14 - 020711 - Glycogen Breakdown and Glycogen...

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1 Glycogen Breakdown and Glycogen Synthesis
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2 Glycogen: Glucose Storage Animals — glycogen Plants — starch Demand in brain and red blood cells, while other tissues can use fatty acids Glucose taken from glycogen supplies in liver for ready supply (~ 5 mM in blood) But, liver’s supply is good only for 1/2 day So, noncarbohydrate sources made into glucose — Gluconeogenesis
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3 Physiological importance of glucose Note: Fats cannot ordinarily be made into glycogen From anaerobic glycolysis Generate NADPH
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a (1—>4)-linked D-glucose a (1—>6) branches every 8-14 residues Many nonreducing ends, one reducing end Alpha what? 4 What is glycogen?
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5 a and b anomers a OH and CH 2 OH opposite sides b OH and CH 2 OH same side Anomeric carbon
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10 Glycogen granules 100-400 Å diameter Contain ~120,000 glucose units 1-2% of muscle weight and Up to 10% of liver weight Contain glycogen synthesis/degradation enzymes Removal of glucoses from nonreducing (many) end, rather than reducing (only one) end
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Liver cell
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Fate of Glycogen
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13 Glycogen Breakdown:
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14 Cleave of Glycogen: phosphorolysis Glycogen n + P i Glucose- 1-P i + Glycogen n-1 Glycogen Phosphorylase In vitro: reversible reaction In vivo: favorable breakdown because [ P i ]/[Glucose- 1-P i ]>100 Difference between G 0 and G
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This note was uploaded on 08/15/2011 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

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Lecture 14 - 020711 - Glycogen Breakdown and Glycogen...

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