Lecture 15 - 020911

Lecture 15 - 020911 - Lecture 15 Glycogen synthesis 1...

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1 Lecture 15 Glycogen synthesis
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2 Glycogen Synthesis: Thermodynamically Unfavorable Glycogen Breakdown Principle: Breakdown and synthesis have key steps that are different
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3 Phosphoglucomutase • Reversible reaction
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4 UDP-glucose Pyrophosphorylase: Activating glucose-1-phosphate From phosphoglucomutase UDP-sugars used frequently, as in glycosylation of proteins
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5 UDP-glucose Pyrophosphorylase: Activating glucose-1-phosphate through a coupled reaction From phosphoglucomutase Coupled Reactions
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6 Coupled Reactions Coupling UDP-glucose pyrophosphorylase to inorganic pyrophosphatase
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7 Glycogen Synthesis
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9 UDP good leaving group - activation of glucose 4 1 4 UDP-Glucose + Glycogen n UDP + Glycogen n+1 Glycogen Synthase
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10 Glycogen granules: How do you start? Glycogen Synthase cannot add glucose + glucose, only glucose + glycogen
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11 How does glycogen start? Tyrosine glucosyltransferase • Attaches glucose to Tyr-194 of the protein glycogenin Glycogenin extends chain up to 7 units using UDP-glucose Glycogen Synthase can act on this primer
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12 Glycogen Synthesis
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Lecture 15 - 020911 - Lecture 15 Glycogen synthesis 1...

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