Lecture 16 - 021111

Lecture 16 - 021111 - 1 Lecture 16 Metabolism of Fatty...

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Unformatted text preview: 1 Lecture 16 Metabolism of Fatty Acids 2 What are fats? Triacyl glycerols 3 Fuel molecules, stored as triacylglycerols Building blocks of phospholipids and glycolipids Covalent attachment of fatty acids to proteins target to membrane Fatty acid derivatives serve as hormones and intracellular messengers Physiological roles of fatty acids 4 More reduced than carbohydrates and proteins complete oxidization of fatty acids ~ 38 kJ/gram carbohydrates ~ 17kJ/gram Triacylglycerols are hydrophobic - anhydrous same energy stored in 11 kg triacylglycerols = 75 kg glycogen In mammals, triacylglycerols stored in adipose (fat) cells Triacylglycerols: highly condensed energy stores Fuel birds migration 5 Mirror reactions 9 Dietary Lipids are digested by lipases Triacylglycerol lipase catalyzes hydrolysis of triacylglycerol -> produce mono- or diacylglycerols Lipase is secreted by the pancreas Absorption aided by bile acids 10 Fatty Acids hydrophobic (not soluble in water) Bile acids (salts) amphipathic (wrap around fats) Cholesterol derivatives synthesized by liver Stored in gallbladder Secreted into small intestine for absorption Also for absorption of lipid-soluble vitamins (A, D, E, K) Solubilization of Fats 17 bloodstream Degraded or stored in adipose tissues & muscle Dietary Lipids are transported in chylomicrons 18 Three stages of utilizing fatty acids energy Triacyl glycerols broken down to fatty acids and glycerol, released from adipose tissue and transported to other tissues fatty acids activated and transported into mitochondria fatty acids broken down to acetyl-CoA -> citric acid cycle Three stages of utilizing fatty acids energy Triacyl glycerols hydrolyzed by lipase 19 Triacyl glycerols hydrolyzed by lipase Hormone (glucogan, epinepherine) controlled In adipose, hormones triggers PKA 20...
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This note was uploaded on 08/15/2011 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

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Lecture 16 - 021111 - 1 Lecture 16 Metabolism of Fatty...

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