Lecture 17 - 021411

Lecture 17 - 021411 - Lecture 17 Fatty Acid Metabolism (II)...

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Unformatted text preview: Lecture 17 Fatty Acid Metabolism (II) 1 Fatty Acid Biosynthesis: Condensation of C2 units Konrad Bloch 1912-2000 Nobel Prize in Physiology or Medicine, 1964 David Rittenberg 1906-1970 2 3 Catabolic and Anabolic Differ Acyl Carrier Protein 4 Acetyl-CoA at the crossroads Fatty Acid Oxidation Pyruvate Demand for Energy High Citric Acid Cycle and Oxidative Phosphorylation Demand for Energy Low Fatty Acid Synthesis 5 CH 3-C ~ O How do you go from here to there? First, you have to get Acetyl-CoA from the mitochondrion to the cytosol Acetyl-CoA 6 Transfer of acetyl CoA to the cytoplasm 7 Tricarboxylate Transport System Add Acetyl-CoA to oxaloacetate - Citric Acid Cycle Transport citrate Reverse citrate synthase = ATP-citrate lyase Use ATP to drive Generate Acetyl-CoA Reverse citric acid cycle Malate dehydrogenase (Use NADH) Oxidative decarboxylation = Malic enzyme Generate NADPH for fatty acid biosynthesis Transport pyruvate back Like gluconeogenesis, pyruvate carboxylase 8 9 Compare with Malate Shuttle also moves NADH into cytoplasm 10 Electrons from cytoplasmic NADH: Malate- aspartate shuttle transporters exist for malate and aspartate oxidize NADH in cytoplasm and reduce NAD + in matrix, one NADH is effectively transported into the matrix malate-aspartate shuttle is prominent in heart and liver Pathway integration 11 Catabolic and Anabolic Differ 12...
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Lecture 17 - 021411 - Lecture 17 Fatty Acid Metabolism (II)...

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