Lecture 21 - 022511

Lecture 21 - 022511 - Lecture 21: Amino Acid Biosynthesis...

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Lecture 21: Amino Acid Biosynthesis (II) 1
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Feedback inhibition regulates amino acid biosynthesis Final products often regulate the committed step. 2
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3-phosphoglycerate dehydrogenase 3-phosphoglycerate dehydrogenase Serine reduces the enzyme V max Abundant serine inhibit the enzyme 3-phosphoglycerate is used for other processes Dimeric regulatory domain 3
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Sophisticated regulation on branched pathways Feedback inhibition and activation Example: Leu, Val, Ile Three pathways compete for the common intermediate - hydroxyethyl thiamine pyrophosphate Balance between amino acids 4
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Sophisticated regulation on branched pathways The committed step catalyzed by different enzymes 6
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Sophisticated regulation on branched pathways The committed step catalyzed by different enzymes Example: three aspartokinases regulate the committed step for synthesizing threonine, methionine and lysine Inhibited by lysine Inhibited by threnonine No feedback inhibition 7
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8 Sophisticated regulation on branched pathways
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Lecture 21 - 022511 - Lecture 21: Amino Acid Biosynthesis...

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