Lecture 24 - 030411

Lecture 24 - 030411 - Lecture 24 Lipids and Steroids...

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Lecture 24 Lipids and Steroids Biosynthesis 1
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2 Lipids synthesis Triacylglycerol Phospholipids: Glycerolipids (most abundant phospholipids) Sphingolipids (enriched in nervous system) Cholesterol
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5 Phospholipids and triacylglycerol synthesis
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6 Common Intermediate of Phospholipids and triacylglycerol synthesis Diacyl-glycerol-3-phosphate Catalyzed by glycerol phosphate acyltransferase In most phosphatidates, R1=saturated fatty acids, R2=unsaturated fatty acids
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7 Triacylglycerol synthesis Catalyzed by two enzymes in a triacylglyerol synthetase complex The synthetase complex bound to the endoplasmic reticulum membrane synthesized in liver, then to muscle or adipose tissues Diacylglycerol acyltransferase phosphatase
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8 Lipids synthesis Triacylglycerol Phospholipids: Glycerolipids (most abundant phospholipids) Sphingolipids (enriched in nervous system) Cholesterol
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9 Phospholipids synthesis starts with activated phosphatidate or alcohol by NTP Activated diacylglycerol Activated by cytidine triphosphate Driven by hydrolysis of pyrophosphate
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10 Structure of the CDP-diacylglyerol
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11 CDP-diacylglyerol then reacts with the hydroxyl group of an alcohol
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If alcohol=phosphatidylglycerol Exclusively located in inner mitochondrial membranes Critical in the organization of protein components of oxidative
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Lecture 24 - 030411 - Lecture 24 Lipids and Steroids...

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