Lecture 25 - 030711

Lecture 25 - 030711 - Final exam Mar 18 3:00pm-5:59pm Sit...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Final exam Mar. 18, 3:00pm-5:59pm Sit one seat apart Fill in the entire bubble Bring ID Fill in ID in scantron bubbles (replace A by 1) Write names on all sheets of exam No calculator
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Lecture 25 Lipids and Steroids Biosynthesis (II)
Background image of page 2
3 Control of Cholesterol Biosynthesis HMG-CoA Reductase, mainly in liver Rate of LDL receptor synthesis Rate of esterification of cholesterol by ACAT
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 HMG-CoA Reductase Membrane protein of ER Responsive to cholesterol levels — increase in HGM-CoA reductase levels (200x) Transcriptional regulation Translational regulation Regulatory degradation Activity regulated by phosphorylation (AMPK) — dephosphorylated form more active
Background image of page 4
5 Direct Effect of Cholesterol: transcription HMG CoA- reductase and ~20 other cholesterol biosynthetic genes Sterol regulatory element binding protein (SREBP) SRECBP cleavage activating protein (SCAP) SCAP: sensor In small vesicles
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 HMG-CoA Reductase • Transcriptional regulation Translational regulation: inhibited by Mevalonate derivatives Dietary cholesterol Regulatory degradation: Membrane domain of the reductase sense [cholesterol] => proteolysis Ubiquitination under some conditions Activity switched off by phosphorylation (AMP-activated Kinase) — cholesterol synthesis stops at low [ATP] All four mechanisms are modulated by receptors that sense cholesterol in the blood.
Background image of page 6
7 Lipoproteins transport cholesterol and triacylglycerols Recognized by target cells LDL
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10 Lipoproteins transport cholesterol and triacylglycerols
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 08/15/2011 for the course CHEM 114B taught by Professor Wang during the Spring '09 term at UCSD.

Page1 / 32

Lecture 25 - 030711 - Final exam Mar 18 3:00pm-5:59pm Sit...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online