Short-review-of-cha_44562 - Control of eukaryotic gene...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
8/17/11 Control of eukaryotic gene transcription Ground state is off – requirement for activators Promoter region usually contains many binding sites for transcription factors and enhancers Besides basal promoter elements like TATA box at -30 and CCAT box around -80, there are enhancers. Enhancers can be located far away, 5’ or 3’, or even in introns of the gene Many transcription factors are modular: DNA binding domain and activation domain (for example, yeast Gal4, lexA) DNA is packed in chromatin: DNA is wrapped around nucleosome: positivly charged proteins. How tightly DNA is bound to these proteins determines whether its regulatory regions can be bound, and whether the gene can be transcribed. The modifications of histones is therefore very important: Everything that reduces their positive charge will lead to loosened up chromatin and better accessibility of the DNA. Hyper-transcribed genes are associated with histones with a lot of modifications (methylation and acetylation)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 08/16/2011 for the course BIOL 1361-1362 taught by Professor Any during the Spring '08 term at University of Houston.

Page1 / 3

Short-review-of-cha_44562 - Control of eukaryotic gene...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online