BIO311C_Spr11_Chapter_17_part_3

BIO311C_Spr11_Chapter_17_part_3 - Mutations Chapter s 17...

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Unformatted text preview: Mutations Chapter s 17 and par t of 16 344-346, 316-318 Fig. 17-22 Wild-type hemoglobin DNA mRNA Mutant hemoglobin DNA mRNA 3 ′ 3 ′ 3 ′ 3 ′ 3 ′ 3 ′ 5 ′ 5 ′ 5 ′ 5 ′ 5 ′ 5 ′ C C T T T T G G A A A A A A A G G U Normal hemoglobin Sickle-cell hemoglobin Glu Val Cause of mutations • Spontaneous mutations – Can occur during DNA replication, repair etc • Mutagens – Are physical or chemical agents that can cause mutations • Point mutations – Are changes in just one base pair of a gene – Can affect protein structure/ function Types of Point Mutations • Point mutations within a gene can be divided into two general categories – Base-pair substitutions – Base-pair insertions or deletions Base pair substitutions I s the replacement of one nucleotide and its partner with another pair of nucleotides • Silent • Missense • Nonsense 1) Silent mutations have no effect on the amino acid produced by a codon because of redundancy in the genetic code Fig. 17-23aFig....
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BIO311C_Spr11_Chapter_17_part_3 - Mutations Chapter s 17...

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