BIO311C_Spr11_Chapter_17_part_3

BIO311C_Spr11_Chapter_17_part_3 - Mutations Chapter s 17...

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Unformatted text preview: Mutations Chapter s 17 and par t of 16 344-346, 316-318 Fig. 17-22 Wild-type hemoglobin DNA mRNA Mutant hemoglobin DNA mRNA 3 3 3 3 3 3 5 5 5 5 5 5 C C T T T T G G A A A A A A A G G U Normal hemoglobin Sickle-cell hemoglobin Glu Val Cause of mutations Spontaneous mutations Can occur during DNA replication, repair etc Mutagens Are physical or chemical agents that can cause mutations Point mutations Are changes in just one base pair of a gene Can affect protein structure/ function Types of Point Mutations Point mutations within a gene can be divided into two general categories Base-pair substitutions Base-pair insertions or deletions Base pair substitutions I s the replacement of one nucleotide and its partner with another pair of nucleotides Silent Missense Nonsense 1) Silent mutations have no effect on the amino acid produced by a codon because of redundancy in the genetic code Fig. 17-23aFig....
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This note was uploaded on 08/18/2011 for the course BIO 1406 taught by Professor Bostic during the Spring '09 term at Austin Community College.

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BIO311C_Spr11_Chapter_17_part_3 - Mutations Chapter s 17...

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