311C_Spr11_chapter 6 p3

311C_Spr11_chapter 6 p3 - Cytoskeleton and extracellular...

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Unformatted text preview: Cytoskeleton and extracellular components Chapter 6 part 3 Cytoskeleton A dynamic structural and functional framework Three types of filaments: A. Intermediate B. Microtubules C. Microfilaments Microfilaments (Actin Filaments) The s truc tura l ro le o f m ic ro fila m e nts is to b e a r te ns io n, re s is ting pulling fo rc e s within the c e ll The y fo rm a 3-D ne two rk c a lle d the cortex jus t ins ide the pla s m a m e m b ra ne to he lp s uppo rt the c e lls s ha pe Fig. 7-7 Fibers of extracellular matrix (ECM) Glyco- protein Microfilaments of cytoskeleton Cholesterol Peripheral proteins Integral protein CYTOPLASMIC SIDE OF MEMBRANE Glycolipid EXTRACELLULAR SIDE OF MEMBRANE Carbohydrate Types of movement mediated by Microfilaments Mus c le c o ntra c tio n C yto pla s m ic s tre a m ing Am o e b o id m o ve m e nt Mic ro fila m e nts tha t func tio n in c e llula r m o tility c o nta in the pro te in myosin in a dditio n to a c tin In m us c le c e lls , tho us a nds o f a c tin fila m e nts a re a rra ng e d pa ra lle l to o ne a no the r Thic ke r fila m e nts c o m po s e d o f m yo s in inte rdig ita te with the thinne r a c tin fib e rs Actin filament Myosin filament Myosin motors in muscle cell contraction. (a) Muscle cell Myosin arm Figure 6.27 A http://www.sciencemag.org/feature/data/1049155s1.mov Am o e b o id m o ve m e nt lo c a lize d c o ntra c tio n o f a c tin a nd m yo s in fila m e nts Cortex (outer cytoplasm): gel with actin network Inner cytoplasm: sol with actin subunits Extending pseudopodium (b) Amoeboid movement Figure 6.27 B http://www.middlesexcc.edu/faculty/Barbara_Bogner/112unittwo.html C yto pla s m ic s tre a m ing Is a no the r fo rm o f lo c o m o tio n c re a te d b y m ic ro fila m e nts Nonmoving cytoplasm (gel)...
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311C_Spr11_chapter 6 p3 - Cytoskeleton and extracellular...

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