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Chapter 18 part 1 BGene regulation in Porkaryotes

Chapter 18 part 1 BGene regulation in Porkaryotes -...

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Regulation of gene expression Chapter 18 Relevant parts
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Control at level of transcription C o ns titutive  e xpre s s io n Re g ulate d e xpre s s io n
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Regulation of gene expression in bacteria Chapter 18 Pages 351-355 Relevant parts only
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Operons: The Basic Concept A c lus te r o f func tio nally re late d g e ne s  c an be   unde r c o o rdinate d c o ntro l by a single on-off “switch” The regulatory “switch” is a segment of DNA called an  operator us ually po s itio ne d within the  pro m o te r An  operon is  the  e ntire  s tre tc h o f DNA that  inc lude s  the  o pe rato r, the  pro m o te r, and the  g e ne s   that the y c o ntro l
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Depending on the type of regulatory molecule that binds operator – two types of regulation: Negative regulation  o c c urs  whe n a re g ulato ry  pro te in binds  to  DNA and s huts  do wn  trans c riptio n. Positive regulation  o c c urs  whe n a re g ulato ry  pro te in binds  to  DNA and trig g e rs  trans c riptio n.
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Regulatory proteins bind operator Ac tivato rs Re pre s s o rs
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Role of regulatory proteins in transcription regulation Role of regulatory proteins in transcription regulation “Turns on” “Turns off”
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