Chapter 18 part 2 BGene regulation in Eukaryotes

Chapter 18 part 2 BGene regulation in Eukaryotes - Gene...

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Unformatted text preview: Gene regulation in eukaryotes pages 356-361 320-323 Differential gene expression • Human cell – expresses 20% genes at a time • Genes expressed in different cells – different Highly packaged DNA cannot be expressed • Heterochromatin – Hig hly c o m pa c te d – No g e ne s e xpre s s e d • Euchromatin – Le s s c o m pa c tio n – G e ne s e xpre s s e d Chromatin condensation silences gene expression CONTROL OF GENE EXPRESSION Fig. 18-6a DNA Signal Gene NUCLEUS Chromatin modification Chromatin Gene available for transcription Exon Intron Tail RNA Cap RNA processing Primary transcript mRNA in nucleus Transport to cytoplasm CYTOPLASM Transcription Fig. 18-6b mRNA in cytoplasm Translation CYTOPLASM Degradation of mRNA Protein processing Polypeptide Active protein Cellular function Transport to cellular destination Degradation of protein Organization of a Typical Eukaryotic Gene • As s o c ia te d with m o s t e uka ryo tic g e ne s a re control elements , s e g m e nts o f no nc o ding DNA tha t he lp re g ula te tra ns c riptio n b y b inding c e rta in pro te ins • C o ntro l e le m e nts a nd the pro te ins the y b ind a re c ritic a l to the pre c is e re g ula tio n o f g e ne e xpre s s io n in diffe re nt c e ll type s Fig. 18-8-3 Enhancer (distal control elements) Proximal control elements Poly-A signal sequence Termination region Downstream Promoter Upstream DNA Exon Exon Exon Intron Intron Exon Exon Exon Intron Intron Cleaved 3 ′ end of primary transcript Primary RNA...
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This note was uploaded on 08/18/2011 for the course BIO 1406 taught by Professor Bostic during the Spring '09 term at Austin Community College.

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Chapter 18 part 2 BGene regulation in Eukaryotes - Gene...

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