2010Exam-two - PRINCIPLES OF EVOLUTION (Fall 2010) _ Name...

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PRINCIPLES OF EVOLUTIO N (Fall 2010) _____________________________ Name 1 Second Exam (1 April 2010) (1) Imagine a gene coding for some protein. The wildtype allele is A (below), and in separate events, mutates to a pair of additional alleles, B (10 th codon mutation) and C (139 th codon mutation). We now have three alleles in the population, though B and C have low frequency. _____DNA_____ ________Protein_______ ( 10 TAT --- 139 AGC ) RNA [ --- Ile --- --- Ser --- ] B ( 10 GAT --- 139 AGC ) RNA [--- Leu --- --- Ser --- ] A ( 10 GAT --- 139 ACC ) RNA [--- Leu --- --- Trp --- ] C (a) Several generations later, we can get a recombination within the confines of this gene, somewhere between codons 10 and 139. Indicate the meiotic products of such intra-genic recombination in the table below, along with their relative frequencies (8 points). Two Alleles Involved Meiotic Products Two Alleles Involved Meiotic Products A with A A with B B with B A with C C with C B with C (b) Remembering that crossing over occurs at the four-strand stage of Meiosis, diagram what happens with intra-genic recombination of B and C (9 points). (c) What is the real evolutionary importance of such rare events? Explain (3 points)
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PRINCIPLES OF EVOLUTIO N (Fall 2010) _____________________________ Name 2 (2) For a two-allele locus (A 1 and A 2 ), we have three genotypes (A 1 A 1 , A 1 A 2 and A 2 A 2 ), each with its own relative fitness. Describe what will happen with each of the following scenarios, and then plot what happens to average population fitness, as a function of time and the frequency of the A 1 allele (
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2010Exam-two - PRINCIPLES OF EVOLUTION (Fall 2010) _ Name...

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