DeNegre Lab 6_2_gene frequencies

DeNegre Lab 6_2_gene frequencies - Lab 6 - Rare Inherited...

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Lab 6 - Rare Inherited Diseases in Humans (continued)
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Have you ever wondered… 1. Why Type O is the most common of the blood types, even though it is a recessive trait?
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Have you ever wondered… 1. Why Type O is the most common of the blood types, even though it is a recessive trait? 2. Why ¾ of the population doesn’t have Huntington's disease, since it is an autosomal dominant trait?
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Have you ever wondered… 1. Why Type O is the most common of the blood types, even though it is a recessive trait? 2. Why ¾ of the population doesn’t have Huntington's disease, since it is an autosomal dominant trait? 3. Why don’t recessive traits gradually disappear from a population, since the majority of individuals are never expressing them?
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To answer these questions, we must think about allelic frequencies within a POPULATION , rather than just within 2 individuals In a cross between individuals Aa and Aa: A = most common allele a = rare allele A A a a
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To answer these questions, we must think about allelic frequencies within a POPULATION , rather than just within 2 individuals In a cross between individuals Aa and Aa: A = most common allele a = rare allele A A a a Let f(A) = p Let f(a) = q f(AA) = p 2 f(Aa) = pq f(Aa) = pq f(aa) = q 2
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To answer these questions, we must think about allelic frequencies within a POPULATION , rather than just within 2 individuals In a cross between individuals Aa and Aa: A = most common allele a = rare allele A A a a Let f(A) = p Let f(a) = q f(AA) = p 2 f(Aa) = pq f(Aa) = pq f(aa) = q 2 For the cross between
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DeNegre Lab 6_2_gene frequencies - Lab 6 - Rare Inherited...

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