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DeNegre Lab 6_HWE_1 - • Single locus with two alleles –...

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Lab 6: Hardy, Weinberg and Kuru
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Rare Genetic Diseases Defective alleles can result in diseases and/or disorders by affecting critical developmental or biochemical functions These defective alleles remain in a family or a population and can be seen in predictable patterns Today’s example is Kuru, Spongy brain disorder Cause: infectious protein in contaminated brain tissue Affected the Foré people of Papau, New Guinea during the early 1900s Result of funereal cannibalism
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Hardy-Weinberg Equilibrium Populations in HWE have constant allele and genotype frequencies over time HWE model assumes: No mutations No selection Random mating Large population size No genetic drift or immigration
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Calculating Allele Frequencies
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Unformatted text preview: • Single locus with two alleles: – Dominant allele frequency = p – Recessive allele frequency = q – p + q = 1 – ALWAYS – Populations in equilibrium: • freq( AA ) = p 2 for the AA homozygotes • freq( aa ) = q 2 for the aa homozygotes • freq( Aa ) = 2 pq for the heterozygotes – p² + 2pq + q² = 1 Calculating Allele Frequencies • HWE equilibrium model:-p² + 2pq + q² = 1 • Used to calculate allele frequencies • Remember: • p 2 = frequency of dominant allele • q 2 = frequency of recessive allele • 2pq = frequency of heterozygotes Today’s Schedule • Lab 6 • In class assignment – TBD • Pick up graded quizzes and last week’s in-class assignment...
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