DeNegre Lab 6_HWE_1

DeNegre Lab 6_HWE_1 - Single locus with two alleles:...

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Lab 6: Hardy, Weinberg and Kuru
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Rare Genetic Diseases Defective alleles can result in diseases and/or disorders by affecting critical developmental or biochemical functions These defective alleles remain in a family or a population and can be seen in predictable patterns Today’s example is Kuru, Spongy brain disorder Cause: infectious protein in contaminated brain tissue Affected the Foré people of Papau, New Guinea during the early 1900s Result of funereal cannibalism
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Hardy-Weinberg Equilibrium Populations in HWE have constant allele and genotype frequencies over time HWE model assumes: No mutations No selection Random mating Large population size No genetic drift or immigration
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Calculating Allele Frequencies
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Unformatted text preview: Single locus with two alleles: Dominant allele frequency = p Recessive allele frequency = q p + q = 1 ALWAYS Populations in equilibrium: freq( AA ) = p 2 for the AA homozygotes freq( aa ) = q 2 for the aa homozygotes freq( Aa ) = 2 pq for the heterozygotes p + 2pq + q = 1 Calculating Allele Frequencies HWE equilibrium model:-p + 2pq + q = 1 Used to calculate allele frequencies Remember: p 2 = frequency of dominant allele q 2 = frequency of recessive allele 2pq = frequency of heterozygotes Todays Schedule Lab 6 In class assignment TBD Pick up graded quizzes and last weeks in-class assignment...
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This note was uploaded on 08/18/2011 for the course GENETICS 382 taught by Professor Staff during the Spring '11 term at Rutgers.

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DeNegre Lab 6_HWE_1 - Single locus with two alleles:...

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