Lecture 14b

Lecture 14b - Cannabis Leaf Cannabis sativa/indica 1...

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1 Cannabis Leaf Cannabis sativa/indica
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2 Δ 9 -tetrahydrocannabinol (THC)
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3 Distribution of Marijuana Use by State Pharmacokinetics of THC
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4 Endocannabinoids Actions of Endocannabinoids Cellular responses to endocannabinoids • Release from cell is triggered by [Ca 2+ ] • not by conventional synaptic release (by diffusion) • postulated mechanism is that Ca 2+ influx causes conversion of endocannabinoid from hydrophilic to lipophilic state allowing it to diffuse through the membrane • Receptors • ** CB1 (neural) • CB2 (immune) • G-protein-coupled metabotropic receptor • primary cellular effects: • located both pre- and post-synaptically • affect the functioning of many other NT systems (Ach, DA, NE, 5-HT, Glutamate, GABA) •inh
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5 One Proposed Mechanism of Action Behavioral & Physiological Effects of Marijuana Behavioral (4 Stages) • Buzz - lightheaded •H igh • euphoria / loss of inhibitions
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This document was uploaded on 08/18/2011.

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Lecture 14b - Cannabis Leaf Cannabis sativa/indica 1...

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