Unformatted text preview: The investigators now have three independent molecular markers that specifically detect arterial cells. Describe the results of this experiment. By testing skin samples from younger embryos (E11 – E14.5 days) it was seen that peripheral nerves (2H3 positive cells) appeared first, and that EphrinB2 positive branching arteries appeared only in the later stages (e.g., weak staining at E13; stronger staining by E15.5). What conclusions may be drawn from these results? The differentiation of arterial endothelial cells occurs only after peripheral nerves have been established. It is therefore plausible that peripheral nerves are responsible for arterial differentiation since their patterning precedes that of the arteries....
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- Spring '08
- DNA, Atherosclerosis, Blood vessel, Tunica intima