bis_104_pq_6_ans_spring_08 - NP1 affected by the Sema3A...

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BIS 104 PQ 6 ans spring 2008 a)What does the Semaphorin3A (Sema3A) gene code for in normal (wild type) mice? The semaphoring 3A gene codes for an axon guidance molecule. b) What do the peripheral sensory nerves in the limb skin of Sema3A mutant mice look like. That is, how are they different from PSNs in wild type mice? In the Sema3A mutant mouse skin, the peripheral sensory nerves are still present, but they branch out in a disorganized fashion, unlike the orderly pattern seen in the wild type mouse . c) How is the immunostaining pattern of arterial endothelial cell markers, such as CX40 and
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Unformatted text preview: NP1, affected by the Sema3A mutation? The staining by the arterial markers reflects the disorganized (following the nerve pattern) branching of the arterial vessels. d) What can be concluded from the experimental results that compare the Sema3A mutant mice with wild type mice? Results suggest that peripheral nerves are not only necessary for arterial differentiation, but are actually sufficient to direct this branching (a gain of function has been demonstrated)....
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