Unformatted text preview: was observed) When undifferentiated ECs were treated with higher concentrations of VEGF (25 and 250 pM) under the same conditions as above, there was no further increase in the number of EphrinB2 positive cells beyond that achieved with 2.5 pM VEGF. What is a possible explanation for this result? Low levels of VEGF were sufficient to saturate all existing VEGF receptors on responding ECs. The remaining 40 - 50% of non-responding ECs may lack functional receptors for VEGF, so no matter how much VEGF is added they will never respond....
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- Spring '08
- Vascular endothelial growth factor, VEGF