Unformatted text preview: provide direct proof of a relationship. (2) Necessity: This category of evidence is obtained through loss of function type experiments where a single suspected causative agent is blocked or inhibited, and its effect on normal activity is determined. (3) Sufficiency: This category of evidence comes from experiments in which the variable of interest is artificially introduced into an experimental system. The system is then monitored to see if there is a gain of function due to the activity or presence of the single variable....
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- Spring '08