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bis_104_pq_8a_ans_08 - How is the marker known as...

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BIS 104 Practice Question 11 a 11. Mukouyama et. al. use the erbB3 mutant, a mouse strain that lacks Schwann cells, to demonstrate that Schwann cells are required for arterial differentiation and blood vessel-nerve alignment. What is the function of the signaling molecule Neuregulin-1? Neurugulin-1 is a signaling factor produced by neurons. It acts on the erbB3 co-receptor on Schwann cells. This interaction is required for the development and survival of Schwann cells.
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Unformatted text preview: How is the marker known as BFABP (brain fatty acid binding protein) used in these erbB3 studies? BFAP is a protein that is produced only by differentiated Schwann cells and therefore, can be used as a marker to identify them. Fluorescently labeled antibodies against BFABP are used to verify the presence of Schwann cells in normal tissue and their absence in the skin tissue in erbB3 mutant mice....
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