bis_104_pq_8a_ans_08

bis_104_pq_8a_ans_08 - How is the marker known as BFABP...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
BIS 104 Practice Question 11 a 11. Mukouyama et. al. use the erbB3 mutant, a mouse strain that lacks Schwann cells, to demonstrate that Schwann cells are required for arterial differentiation and blood vessel-nerve alignment. What is the function of the signaling molecule Neuregulin-1? Neurugulin-1 is a signaling factor produced by neurons. It acts on the erbB3 co-receptor on Schwann cells. This interaction is required for the development and survival of Schwann cells.
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: How is the marker known as BFABP (brain fatty acid binding protein) used in these erbB3 studies? BFAP is a protein that is produced only by differentiated Schwann cells and therefore, can be used as a marker to identify them. Fluorescently labeled antibodies against BFABP are used to verify the presence of Schwann cells in normal tissue and their absence in the skin tissue in erbB3 mutant mice....
View Full Document

This note was uploaded on 08/18/2011 for the course BIS 104 taught by Professor Scholey during the Spring '08 term at UC Davis.

Ask a homework question - tutors are online