bis_104_pq_8b_ans_08 - It must be remembered that in the...

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BIS 104 Practice Question 11 b 11. Mukouyama et. al. use the erbB3 mutant, a mouse strain that lacks Schwann cells, to demonstrate that Schwann cells are required for arterial differentiation and blood vessel-nerve alignment. Why was it important in these studies to show that erbB3 is not normally expressed in endothelial cells are they differentiate?
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Unformatted text preview: It must be remembered that in the erbB3 mutant strain of mice, the erbB3 gene is defective in all cells of all tissues, not just in the Schwann cells. So the failure of arteriogenesis in erbB3 mice could also be explained if endothelial cells themselves need to express the erbB3 gene for their normal differentiation....
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