PHGY 209 - Blood

PHGY 209 - Blood - 09-29-10 September 29, 2010 11:35 AM...

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Hematoma = bruise ---> internal bleeding ( loss of blood to the tissues) Hemostasis - the arrest of bleeding following vascular injury Interacting, overlapping mechanisms ---> 3 groups of factors Vascular response: decrease of the loss of blood primary hemostasis - Platelet response: clotting of the opening emergency response (in sec) - Clot formation: longer last blood clot secondary (in min) - Platelets (2-4 um) < RBC (7 um) --> no nucleus either --> many granules : factors for vasoconstriction, clotting, growth --> many filaments : microtubules, lots of mitochondria, sER --> ~ 250,000 - 400, 000/uL --> one week lifespan Same pattern of development as RBC Platelet production (review mechanism of production of RBC) Pluripotentioal stem cell - myeloin - thrombopoietin - 7 - 10x mitosis w/ nuclear/cytoplasmic div. -> becomes a MEGAkaryocytes (HUGE compared to the committed stem cell) Platelets = discs Platelet plug formation Platelets have an imp. Properties of not sticking to normal endothelium, everything else, it
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PHGY 209 - Blood - 09-29-10 September 29, 2010 11:35 AM...

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