PHGY 209 - Body fluids

PHGY 209 - Body fluids - Milieu interieur = various body...

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Unformatted text preview: Milieu interieur = various body fluids Aspects of body fluid Volume, distribution, characteristics, functions Dissolves solutes- Metabolic rx- Skin has 70% water- Muscle (largest proportion of body mass) 75%- Organs 70-80%- *size is not a big factor for the gain of water %age Bone 25% most is solid- Fat 10% (adipose tissue) - *fat is big variable determining the %age of water mass 60% water, very little solid, less fat than water Obese individual 45% water (however same amount of water), same very little solid, more fat than water. Very thin 75% water (however same amount of water), very little solid, and very little fat Ex: average individual We all have about the same %age of water in us. Most abundant: water (45% to 75% of total body mass) Even if the standard values of an individual is 21yo, white, 70kg… keep in mind that there are way more kinds of variety. Variations of body water with age and gender New born : 75% New born has not much adipose tissue, until later on. But starts decreasin at puberty. Woman: 50% At puberty, the distribution of body fat starts to show Man: 60% Older male : 50% The muscle is replaced by fat Older female : 45% 08-03-10 Body fluids Page 1 Gradual change of body water %age- *page 10 not to memorize* Average 70kg male About 42L of water Average 60kg female About 30L of water *extra* 70kg male : 42L h20 = 42, 000 mL Administer 100mg medication Final 100/42,000 = 0.0024 0.24 mg/ml *** Screen clipping taken: 03/09/2010, 12:00 PM Kidney = homeostatic regulator Obligatory losses will happen no matter what Facultative losses vary by intake Insensible perspiration Sweating Pure water Electrolyte sol'n Passive evaporation (affected by ambient T' & relative humidity) Active secretion Entire skin surface (present even in individuals lacking glands Sweat glands Continuous Activated by heavy work or high T' Water, coke, juice... sugar Lose water by evaporation through: You are not aware of this Obligatory for elimination of wastes Body fluids Page 2 *over the 24h period, the turnover of water in the adult is 3-4% of body weigh *In the infant it is 10% of total body weight Reduced intake- Excessive loss from gut- Excessive sweating- Excessive loss in expired air (high places, air is dryer, enhances evaporation, increases of breathing = breath = (+) vapor water loss)- Excessive loss in urine- Screen clipping taken: 03/09/2010, 12:18 PM These compartments are all permeable to water Negative water balance Intracellular fluid is 2/3 of body water ICF = 40% of body mass- Extracellular fluid only takes 1/3 ECF = 20%- Body fluids Page 3 ECF compartments 2 major subcompartments Plasma- Interstitial fluid (ISF)- 2 minor subcompartments Lymph- Transcellular fluid- ISF (interstitial fluid) Between the cells • Actual milieu interieur of the individual cells • Medium of cell exchange • Screen clipping taken: 08/09/2010, 11:43 AM ***lymph endings at individual cells*** Screen clipping taken: 08/09/2010, 11:45 AM Transcellular fluid...
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This note was uploaded on 08/20/2011 for the course PHGY 209 taught by Professor Wechsler during the Fall '07 term at McGill.

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PHGY 209 - Body fluids - Milieu interieur = various body...

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