Lect 31 -Feb23 - Renal III

Lect 31 -Feb23 - Renal III - total volume of ltrate...

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!"#$%$ '()*+ H,K -B*)7/.B9 J(9I(() -5J5+*B 4+50@ *)@ "(B095J5+*B L*/0++*B0(7 34 ?7.#'$,//"/.7 -&"*, A D(=JB*)( 9B*)7/.B9(B7 .) */01*+ [+5=0)*+\ *)@ J*7.+*9(B*+ =(=JB*)(7 .8 (/09:(+0*+ 1(++7 A v*9(B L:*))(+7 [>^5*/.B0)7\ */01*+ *)@ J*7.+*9(B*+ =(=JB*)(7G 84 [.7.$,//"/.7 -&"*, A =.](=()9 .8 I*9(B 9:B.5F: 7/*1(7 J(9I(() (/09:(+0*+G A v*9(B *+I*<7 =.](7 @.I) * :<@B.79*61 *)@S.B .7=.61 FB*@0()9G _9 07 )(](B *16](+< 9B*)7/.B9(@G A #5+C m.I .8 I*9(B J(9I(() 1(++7 @.I) * :<@B.79*61 *)@S.B .7=.61 FB*@0()9G A -:07 J5+C m.I .8 I*9(B 1*) @B*F .B 1*BB< @077.+](@ 7.+59( I09: 09 A 0&/:,#* =7.B G A '(7/.)70J+( 8.B B(*J7.B/6.) .8 !* [*+.)F I09: =(=JB*)( 9B*)7/.B9(B7\ A 3 ;.+]()9 @B*F [*)@ !* '(*J7.B/6.)\ @.(7 ).9 :*]( * 9B*)7/.B9 =*O0=5=G TRANSCELLULAR PARACELLULAR APICAL MEMBRANE BASOLATERAL MEMBRANE Routes of Epithelial Transport LUMEN PERITUBULAR SPACE CAP tight junction Solvent Drag or Bulk Flow (Variation Permeability) Transporters Exchangers Transporters Exchangers $$K '()*+ %c Z*)5*B< HHV H%$$ $d total volume of Fltrate reabsorbed in the PT = 85% of G±R. 100% glucose, 100% amino acids, 85% HCO3-, 66% Na+. Primary reduction in total volume related to reabsorption of water and the ability of the water/solute to pass to the peritubular capillaries via 2 routes: transcellular and paracellular. Regulation of Na+ reabsorption is a ssociated with changes in volume regulation. If hypovolemic or hyperosmotic going to conserve Na+ --> reabsorb more water. hypervolemic or hypoosmotic going to excrete Na+ --> excrete more water. Na/K-ATPase sets up electrical gradient for transport across the apical membrane. junctions between cells are very permeable to water. The concentration of proteins in the peritubular capillaries is increased, therefore the oncotic pressure is increased. This is the primary driving force for peritubular capillary reabsorption of water. spaces between epithelial cells are big enough to allow solutes in solution (water) to move across though the paracellular route ==> solvent drag. Na+ reabsorption throug the transcellular route requires membrane transporters, which have a transport maximum. Na+ is subject to solvent drag though the paracellular route, therefore there is no transport maximum for Na+.
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!"#$%$ '()*+ H,c '(*J7.B/6.) .8 9:( U+.=(B5+*B 40+9B*9( J< 9:( [7&6<2./ 9&#:&/"*,> ?"L"/, Q 0,$7,%&# <#*& *+, [7&6<2./ ?"L"/, Q](B]0(I 3 ldk .8 9:( 9.9*+ U+.=(B5+*B 40+9B*9( ].+5=( B(*J7.BJ(@ 0) 9:( /B.O0=*+ 95J5+( 3 ^^Z &) *+, e/*,7,> /&.> &) ;. 07 B(*J7.BJ(@ [ 9&#'*.#* !7.$%&#./ ;. -,.L'&7V%&# \ A '(F*B@+(77 .8 9:( T+9(B(@ +.*@ .8 !*V eek I0++ J( B(*J7.BJ(@ *)@ KKk I0++ J( (O1B(9(@G 3 3YYZ e/*,7,> B/"$&', .#> .2<#& .$<>' *B( B(*J7.BJ(@ 0) /B.O0=*+ 95J5+(G 3 jTZ &) *+, e/*,7,> I9OAH [.](B ooGok .8 9:( 9.9*+ T+9(B(@ +.*@ .8 XLQK, B(*J7.BJ(@ J< 9:( )(/:B.)7\ 3 [j d%k .8 9:( T+9(B(@ +.*@ .8 5B(* 07 B(*J7.BJ(@ A 8.++.I7 B(*J7.B/6.) .8 I*9(BG\ 3 _) *@@06.) 9. 40+9B*6.)V ',$7,%&# &) IJ N.#> IJ .' ;IFJP f",'%&# ` v:*9 I0++ :*//() 9. 9:( 95J5+*B m50@ 1.)1()9B*6.) .8 * 75J79*)1( *7 09 =.](7 *+.)F 9:( /B.O0=*+ 95J5+( [*)@ )(/:B.)\ 08 9:( 75J79*)1( 07 T+9(B(@ J59 ).9 B(*J7.BJ(@ *)@ ).9 7(1B(9(@u Z*)5*B< HHV H%$$ $e kidney has the capacity to excrete H+ as NH4+ (ammonium ion). NH4+ is excretd with a SO3- (sulfate) anion, so it does not deplete the body of bu f er base (HCO3-).
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!"#$%$ '()*+ H,d =,*.</' &) -,.L'&7V%&# Q 0,$7,%&# <# *+, [7&6<2./ ?"L"/, ".0)97` 3 #*7.+*9(B*+ =(=JB*)( !*S? >-"*7( /5=/ F()(B*9(7 9:( (+(19B.1:(=01*+ FB*@0()9 8.B B(*J7.B/6.) .8 75J79*)1(7 8B.= 95J5+*B m50@ 0)9. (/09:(+0*+ 1(++7 *)@ 9:() =.](=()9 0)9. 9:( /(B095J5+*B 1*/0++*B0(7G 3 U+51.7(V >> a .9:(B =.+(15+(7 B(*J7.BJ(@ J< ;(1.)@*B< >16]( -B*)7/.B9 A 1. 9B*)7/.B9, I09: !*G 3 !* *+7. B(*7.BJ(@ J< /*B*1(++5+*B 7.+]()9 @B*F .8 I*9(BG 3 Q9:(B =.+(15+(7 *)@ 0.)7 *+7. B(*J7.BJ(@ J< /*B*1(++5+*B 7.+]()9 @B*FG 3 v*9(B B(*J7.B/6.) .115B7 9:B.5F: 9:( /*B*1(++5+*B *)@ 9B*)71(++5+*B /*9:I*<7G 3 v*9(B 07 *+I*<7 B(*J7.BJ(@ @.I) * :<@B.79*61 *)@S.B .7=.61 FB*@0()9G _9 07 !NRN' *16](+< B(*J7.BJ(@G 3 ldk .8 T+9(B(@ +.*@ .8 XLQK, B(*J7.BJ(@ *1B.77 9:( */01*+ =(=JB*)( *7 LQHG XLQK, B(F()(B*9(@ I09:0) 1(++ B(*J7.BJ(@ *1B.77 J*7.+*9(B*+ =(=JB*)( J< 8*10+09*9(@
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Lect 31 -Feb23 - Renal III - total volume of ltrate...

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