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Unformatted text preview: Understand the effect of current spread into the transverse tubule and the effect of this current on the dihydropyridine receptor (DHP Receptor) and the Ryanodine Receptor (RyR1) on the lateral sacs of the sarcoplasmic reticulum. Recognize that the initial activation of the RyR1 receptor opens calcium channels in the lateral sacs initiating release of calcium stores. Understand the concept of calcium induced calcium release (CICR) from Ryanodine channels in the lateral sacs after the initial calcium release by activation of the DHP–RyR1 channel. 3. Understand the sequence of steps in cross-- bridge formation and cross-- bridge cycling in ‐ ‐ skeletal muscle. Understand the role of calcium in unmasking the myosin binding sites of actin and the dual role of ATP in cross-- bridge cycling. ‐...
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- Winter '08