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Clearance 2010 - Physiol Mol Biol Animals Spring 2010...

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RENAL CLEARANCE Clearance , C x , for any substance x is defined as the ratio UV/P where U = urine concentration of a solute, mg/ml V = urine flow rate, ml/min P = Plasma concentration of a solute, mg/ml Clearance is a measure of the volume of plasma completely freed of a given substance per minute by the kidneys. If a compound is only filtered by glomeruli and is neither secreted nor reabsorbed by the tubules, the clearance of this compound directly measures the glomerular filtration rate (GFR). Example : Inulin (a compound that is neither secreted nor reabsorbed) GFR x [ inulin ] in blood = inulin that passes into tubule GFR x [ inulin ] in blood = [ inulin ] in urine x urine flow rate or , GFR = (UV)/ P = clearance of inulin, C in Clearance is a measure of the amount of plasma that would have to be completely filtered or “cleared” of the substance every minute to provide the quantity of substance found in the urine. If clearance of a substance clearance of inulin, the substance is secreted If clearance of a substance <
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