LectGasExchange3 - Vertebrate Lungs Large variation in...

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Vertebrate Lungs Large variation in complexity: saccular (lungfish, amphibians, some reptiles) alveolar (some reptiles, mammals) parabronchial (birds)
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Fractal model of air-filling tree
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1500 ml 3150 ml 170 ml Adult human total capacity ¾ inflation Dead air spaces ( See text p. 437 ) 3-6 x 10 8 1 x 10 4
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convection
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Normal Emphysema (chronic obstructive pulmonary disease) cigarette smoking macrophages proteolytic enzymes destroy elastic fibers kill cells destroy alveolar walls less surface area
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cigarette smoke irritates cilia coughing “chonic bronchitis”
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Diffusion Pathways: Small! 0.2 μm capillary Red Blood cell air
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Air space Air space septa Blood capillary
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Gas exchange at alveoli alveolar capillary
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100 mm Hg 40 mm Hg 100 mm Hg Gas exchange at alveoli “diffusing capacity” or conductance, G alveolar capillary
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Ventilation positive pressure breathing – fish, amphibians negative pressure breathing – reptiles, mammals, birds
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largely passive (elastic recoil) except during exercise
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Spirometer
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See Text pp. 443
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air wa ter
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Dilution Technique Functional residual capacity helium
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This note was uploaded on 08/24/2011 for the course PCB 4723C taught by Professor Julian during the Fall '08 term at University of Florida.

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LectGasExchange3 - Vertebrate Lungs Large variation in...

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