Lecture Acid-Base - Acid-Base Physiology Acid-Base Balance...

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Acid-Base Physiology
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Acid-Base Balance Blood is slightly alkaline in animals In all animals, the ratio of OH - to H + in blood is about 20. The neutral pH (pN) of water decreases at higher temperatures. Therefore, plasma pH is higher for ectotherms living in cold environments. In mammals at 37 °C, normal arterial blood pH is 7.40 (lethal limits are ~6.8 and 7.7).
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Acid-Base Balance pH of various biological fluids 8.1 Pancreas secretions 7.5 Mitochondrial matrix 7.34 – 7.45 Blood 7.3 Cerebrospinal fluid (CSF) 7.2 Cytosol 6.81 Neutral H 2 O at 37 °C 6.0 Urine 5.5 Granules of chromaffin cells 4.5 Lysosomes 0.7 Gastric acid pH Compartment http://en.wikipedia.org/wiki/PH
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Proteins are usually the first to go when pH varies In mammals and birds , pH is strictly regulated because pH imbalances disturb physiological systems – mostly proteins. Protein (enzymes, receptors, etc) conformation is heavily dependant upon their milleu (e.g. pressure, temperature, charge, pH), and proteins will lose their function at pH’s outside a set range. In ectotherms , pH varies with body temperature. The alphastat hypothesis argues that the temperature-dependent pH changes are adaptive to keep proteins in their functional state. The buffering capacity (H + affinity) of imidazole groups on proteins decreases with temperature. Thus, at higher temperatures, less imidazole groups will be bound to protons, affecting the function. Increasing the available protons at high temperatures (decrease in pH)
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Lecture Acid-Base - Acid-Base Physiology Acid-Base Balance...

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