Oxidative Stress_10-2010_final

Oxidative Stress_10-2010_final - OxidativeStress...

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Oxidative Stress Stephanie Wohlgemuth Assistant Professor Dept. of Animal Sciences
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What’s next? Beginning of the next topic will be Thursday, October 14. By: Jonie Wright on Water Balance and Osmoregulation
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What is oxidative stress? Oxidative stress represents an imbalance between the production of reactive oxygen species (ROS) a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.
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What is oxidative stress? Imbalance ROS detoxification / repair Involved in many diseases : e.g., atherosclerosis, Parkinson's disease, heart failure, myocardial infarction, Alzheimer's disease, schizophrenia, bipolar disorder, fragile X syndrome, chronic fatigue syndrome–and also in aging
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What is oxidative stress? Imbalance ROS detoxification / repair Involved in many diseases and aging Short term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis .
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What is oxidative stress? Imbalance ROS detoxification / repair Involved in many diseases and aging Mitohormesis Beneficial effects of ROS : they are used by the immune system as a way to attack and kill pathogens. Reactive oxygen species are also used in cell signaling (redox signaling).
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What is oxidative stress? Imbalance between reactive oxygen species and detoxification a/o repair Involved in many diseases Mitohormesis . Beneficial effects of ROS: immune system, redox signaling.
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Lecture Overview Free Radicals, Reactive Oxygen Species (ROS) Mitochondria Beneficial: immune system, redox signaling. Detoxification, Antioxidants Repair Oxidative damage Exercise Aging Animals
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Free radicals and activated species What are free radicals? A free radical is any species capable of independent existence (‘free’) that contains one or more unpaired electrons ( Halliwell and Gutteridge, “Free radicals in Biology and Medicine”, 4 th ed., 2007 ) Unpaired electron: occupies an atomic or molecular orbital by itself Radicals can be formed by losing a single electron ( X–e X .+ ) gaining a single electron from a non radical ( Y + e Y . ) Oxidation Reduction
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Superoxide ion: O 2 . e parallel spin
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